> ## Documentation Index
> Fetch the complete documentation index at: https://kalarislabs.com/llms.txt
> Use this file to discover all available pages before exploring further.

# esm — AI agent skill for life sciences

> Covers the EvolutionaryScale/Biohub `esm` Python SDK: ESM3 generative protein design (sequence, structure and function tracks, chain-of-thought), ESMC emb…

# `esm`

> Covers the EvolutionaryScale/Biohub `esm` Python SDK: ESM3 generative protein design (sequence, structure and function tracks, chain-of-thought), ESMC embeddings, inverse folding, ESMFold2 structure prediction, and hosted Forge/Biohub inference with ESM\_API\_KEY. Use when generating or completing proteins with ESM3, extracting ESMC embeddings for classification or similarity, folding a sequence or designing sequences from a structure, or choosing between esm3-open, esmc\_300m and Forge-hosted models. Use when batching async Forge or Biohub API calls. Not for other protein models such as AlphaFold or generic Hugging Face transformers usage.

**Category:** [life-sciences](/skills#life-sciences) · **License:** MIT · **Version:** 1.2

## Install

```bash theme={null}
npx research-agent-skills install esm
npx skills add KalarisLabs/research-agent-skills --skill esm
```

## When to use it

Covers the EvolutionaryScale/Biohub `esm` Python SDK: ESM3 generative protein design (sequence, structure and function tracks, chain-of-thought), ESMC embeddings, inverse folding, ESMFold2 structure prediction, and hosted Forge/Biohub inference with ESM\_API\_KEY. Use when generating or completing proteins with ESM3, extracting ESMC embeddings for classification or similarity, folding a sequence or designing sequences from a structure, or choosing between esm3-open, esmc\_300m and Forge-hosted models. Use when batching async Forge or Biohub API calls. Not for other protein models such as AlphaFold or generic Hugging Face transformers usage.

## Full playbook

Read [SKILL.md](https://github.com/KalarisLabs/research-agent-skills/blob/main/skills/esm/SKILL.md) for the complete workflow, references and any scripts. The agent installer copies the full skill folder.