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experimental-design

Category: ideation-and-design · License: MIT · Version: 1.2 · Includes scripts Tags: experimental design, randomization, blocking, study design, statistics

When to use it

Design experiments and studies BEFORE data is collected — choosing a design, randomizing, blocking, and laying out treatment combinations so results are interpretable. Use whenever someone is planning a study, asks how to assign subjects/samples to groups, mentions randomization, blocking, stratification, controls, factorial or fractional-factorial designs, design of experiments (DOE), screening many factors, response-surface optimization, crossover or repeated-measures or split-plot designs, cluster/group randomization, Latin squares, plate layouts, batch/run-order effects, replication vs. pseudoreplication, or sequential/adaptive/group-sequential designs. Trigger even for informal phrasings like “how should I set up this experiment”, “how do I avoid confounding”, “what’s the best way to test these 6 factors”, or “assign these mice to conditions”. For computing the sample size or power once the design is chosen, use statistical-power; for analyzing data already collected, use statistical-analysis.

Example requests

Ask your agent in plain language, for example:
  • “how do I assign 24 mice to 4 drug conditions without bias?”
  • “I’m running a qPCR study on 48 liver samples (24 treated, 24 control) in 96-well plates, and the plate_layout.csv I drafted has all the controls in columns 1-2 and treated samples in the rest. Two technicians will split the work across two days. Can you help me redo the layout so I don’t get plate or day artifacts?”
  • “We have 7 process parameters for a fermentation (temperature, pH, feed rate, agitation, inoculum size, and so on) and each run costs about $2k, so we can afford maybe 16 runs. We want to find which ones matter and then tune the important ones to maximize titer. What’s a sensible plan?”

Install

In Claude Code you can also add the marketplace with /plugin marketplace add KalarisLabs/research-agent-skills and install the whole ideation-and-design category with /plugin install ideation-and-design@research-agent-skills.

Full playbook

Read SKILL.md for the complete workflow, references and any scripts. The agent installer copies the full skill folder.
Last modified on October 19, 2026