pkpd-modeling
Category: chemistry-and-drug-discovery · License: MIT · Version: 1.2 · Includes scripts
Tags: pharmacokinetics, pharmacodynamics, PK/PD, drug development, pharmacology
When to use it
Pharmacokinetic and pharmacodynamic modelling and simulation - non-compartmental analysis, compartmental and population PK, PK/PD and exposure-response, TMDD, PBPK orientation, bioequivalence, allometric scaling and first-in-human dose, drug interaction prediction, and Bayesian therapeutic drug monitoring. Use when analysing concentration-time data, deriving exposure metrics, fitting PK or PD models, or evaluating dosing regimens. Triggers include “pharmacokinetics”, “pharmacodynamics”, “PK/PD”, “NCA”, “non-compartmental”, “AUC”, “Cmax”, “lambda z”, “half-life”, “clearance”, “volume of distribution”, “compartmental model”, “population PK”, “popPK”, “NONMEM”, “nlmixr2”, “Pharmpy”, “Monolix”, “exposure-response”, “Emax”, “EC50”, “indirect response”, “effect compartment”, “TMDD”, “PBPK”, “bioequivalence”, “RSABE”, “ABEL”, “allometric scaling”, “first-in-human”, “MABEL”, “drug-drug interaction”, “DDI”, “ICH M12”, “concentration-QTc”, “therapeutic drug monitoring”, “MIPD”, and “dosing regimen”.Example requests
Ask your agent in plain language, for example:- “How do I get the half-life and AUC from my plasma concentration data after an oral dose?”
- “I’ve got a NONMEM-style CSV, study101_pk.csv, with columns ID, TIME, AMT, ADDL, II, DV, EVID, WT. Some DV cells say ‘BLQ’ and a few WT cells are blank. Before I run my two-compartment model, what should I check, and will NONMEM choke on this?”
- “We’re planning a twice-daily regimen for a new antibiotic with high between-patient variability in clearance. I want to know what share of patients would keep their trough above the target concentration, not just what the average patient does.”
Install
/plugin marketplace add KalarisLabs/research-agent-skills and install the whole chemistry-and-drug-discovery category with /plugin install chemistry-and-drug-discovery@research-agent-skills.